The bug mentioned by nitanwar can be found here: Bug#4098313 - AIR application can't be started under Mac OS X
I totally agree with StudioCloud that hacky workarounds are not a solution and that the problem should not have occured in the first place.
Dear Adobe staff, when will this bug be fixed? Since 8th of December - almost a month now! - our Mac users have this problem. Since uninstall/reinstall does not work for most, we advise them to downgrade to AIR 19 which is a security nightmare in the long run.