This happens 100% of the time. If I am using a web browser when Adobe Air has an update, the Air updater pops up and completely hard locks my computer. I can move the mouse, but otherwise, nothing works. Ctrl+Alt+Del (and all other keystrokes) are disabled, mouse clicks do nothing. The only option at that point is to hold the power button in until the whole system shuts down, losing all of my unsaved work and possibly causing damage to hardware components.
I'm using a Lenovo ThinkPad T540p with Windows 7 and all the latest updates - a very healthy computer otherwise. This and Dreamweaver are the only two applications which have ever crashed this particular computer.